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In stockCJC-1295
CJC-1295 no DAC
CJC-1295 no DAC is supplied as 10mg lyophilised powder for laboratory research. Price is shown in your currency, and its Certificate from a named outside laboratory is published on this page. Not for human or veterinary use.
Size10mgPurity99.94%FormulaC152H252N44O42
CJC-1295 without DAC (also called Modified GRF 1-29) is a synthetic analogue of the first 29 amino acids of growth hormone-releasing hormone (GHRH), the hypothalamic signal that tells the pituitary to release GH. Without the Drug Affinity Complex modification it has a short half-life, making it useful for studying pulsatile GH release in preclinical models.
€67
Quantity
HPLC verified
9–14 day shipping
Full COA
Worldwide delivery
About this compound
The research profile.
CJC-1295 is a synthetic analogue of growth hormone-releasing hormone built on the GHRH(1-29) sequence — the shortest fragment of the native hormone that retains full activity at the GHRH receptor. Four amino-acid substitutions protect it against enzymatic degradation, principally cleavage by dipeptidyl peptidase-4, which limits the useful life of unmodified GHRH(1-29) to a few minutes.
This vial is the no-DAC form, also written as Modified GRF (1-29). It omits the drug affinity complex — the maleimide group that, in the DAC version, binds covalently to circulating albumin and stretches the half-life into days. Without that group the molecule clears far faster, so the GH signal it produces is a short pulse rather than a sustained elevation. The published DAC pharmacokinetics (a 5.8–8.1 day half-life, with plasma GH raised for six days or more after a single injection) describe the DAC construct and should not be read onto the no-DAC form.
Mechanistically the compound works upstream of the pituitary rather than replacing growth hormone itself: it prompts somatotrophs to release their own stores. Human work with the long-acting analogue reports that pulsatile GH secretion persists during continuous receptor stimulation, indicating that the underlying secretory rhythm is not abolished by sustained GHRH-receptor signalling. Because GHRH and ghrelin-receptor pathways are separate, GHRH analogues are commonly co-studied with GHS-R1a agonists such as ipamorelin.
Published research
16 peer-reviewed studies on CJC-1295 are summarised in our research library, including 8 published since 2023 — with study designs, reported findings and what the evidence does not establish.
Read the CJC-1295 evidence baseFor research purposes only. Not for human consumption, diagnosis, treatment, or prevention of any condition.
Categorised as Hormones — GH secretagogues, recombinant GH and gonadotropins.
Dosing at a glance
What the literature reports.
For research and laboratory use only. Not for human consumption.
Route
Subcutaneous
Frequency
1–2x daily for no-DAC protocols
Reported range
100–300 mcg
Protocol duration
4–7 weeks (published trial durations)
100 mcgper administration300 mcg
The published human trials of the DAC construct ran 28 and 49 days at ascending weekly doses on a per-kg basis; no-DAC protocols in the literature use much smaller, more frequent amounts because the molecule clears within hours. The 100–300 mcg figures shown reflect the per-administration amounts reported for the no-DAC form and describe research designs only.
Ranges reflect protocols reported in the published literature on CJC-1295 — see research citations.
Calculate a dilutionReconstitution & storage
From powder to solution.
- Step 01
Add 2 ml bacteriostatic water
Aim the stream at the vial wall rather than the powder.
- Step 02
Swirl gently — never shake
Rotate the vial until the solution runs clear. Agitation degrades the peptide.
- Step 03
Refrigerate at 2–8 °C
Reconstituted vials belong in the fridge, protected from direct light.
- Step 04
Use within 28 days
Discard any remainder once the stability window closes.
Lyophilised · −20 °CReconstituted · 2–8 °C, 28 days
Reconstituted solution is typically held at 2–8 °C and protected from light; sealed lyophilised vials are stored at -20 °C.
Reconstitution calculator
10 mg vialmg
ml
mcg
300 mcg = 0.3 mg
Draw
6units · U-100 insulin syringe
- Concentration
- 5 mg/ml
- Draws per vial
- 33
- Cost per draw
- €2.03
For research and laboratory use only. Not for human consumption.
Laboratory arithmetic for CJC-1295 — enter the COA-verified vial content for exact figures. Not medical advice.
Effect timeline
Observed across the research window.
Milestones summarise findings reported in the cited studies. Outcomes vary across models and protocols.
Minutes 0–120
GHRH-receptor stimulation
Binding at the pituitary GHRH receptor prompts somatotroph release of stored growth hormone. For the no-DAC form this appears in the literature as a short pulse, since the molecule is cleared within hours rather than days.
Days 1–6
What the DAC data actually show
After a single injection of the albumin-binding DAC construct, investigators recorded mean plasma GH raised 2- to 10-fold for six days or more and IGF-I raised 1.5- to 3-fold for 9–11 days, with a half-life of 5.8–8.1 days. These figures belong to the DAC version and are not transferable to no-DAC vials.
Week 2
Pulsatility under continuous stimulation
Follow-up human work reported that GH secretion remained pulsatile during continuous GHRH-receptor stimulation, indicating the endogenous secretory rhythm was not abolished by sustained signalling.
Protocol end points
Animal-model comparators
In GHRH knockout mice, daily administration produced growth measures comparable to controls, while 48- and 72-hour intervals produced intermediate results — a dosing-frequency comparison often used as the reference point for study design.
For research and laboratory use only. Not for human consumption.
Scientific research
The published evidence.
The dosing ranges and timeline milestones on this page summarise the peer-reviewed publications below.
References
- 01
Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab (2006). PubMed · 16352683
- 02
Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab (2006). PubMed · 17018654
- 03
Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab (2006). PubMed · 16822960
- 04
Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone. J Clin Endocrinol Metab (1990). PubMed · 2108187
Laboratory verification
One Certificate, published unaltered.
The Certificate is a test report from a named laboratory outside AKH, ordered by our manufacturer and shown here exactly as the laboratory issued it. A printed copy ships in every parcel.
- Batch
- 26082
- Test date
- 02 Aug 2026
- Task ID
- #1812378
- Purity
- 99.94%
Results
CJC 1295 no DAC: 10mg | Purity: 99.94%
Verified by Brown Institute of Biomolecular Research. Scan the full report for every measurement.
Product FAQ
Questions researchers ask.
Pairs well with
Frequently co-studied.
Compounds that appear alongside CJC-1295 in the research literature.
For research and laboratory use only. Not for human consumption.
From the blog
Further reading.
- Research notes
CJC no DAC vs CJC with DAC: what the difference is
CJC no DAC and CJC with DAC are two different molecules: the DAC version carries a drug affinity complex that binds albumin and extends its reported half-life to days, while the no-DAC form clears within hours. What the naming means, what the literature actually compared, and which form the published AKH batch record documents.
Read the post - Research notes
Tesamorelin half life and the CJC-1295 comparison
Tesamorelin's half life is not reported as a single figure in the supplied literature, while CJC-1295 with DAC carries a reported 5.8 to 8.1 day half life. What the sources do and do not establish, and what a cloudy reconstituted solution indicates about handling.
Read the post
Hormones
