New
Hormones· New
Sold outKisspeptin-10
Kisspeptin-10 (KP-10)
Size10mgPurity99.54%FormulaC63H83N17O14
A 10-amino-acid neuropeptide and the active C-terminal fragment of kisspeptin. Studied as an upstream stimulator of GnRH neurons and the downstream LH/FSH cascade in reproductive endocrinology research.
€50
Quantity
HPLC verified
9–14 day shipping
Full COA
Worldwide delivery
About this compound
The research profile.
Kisspeptin-10 is the shortest fully active fragment of the kisspeptin family — a decapeptide cleaved from the larger kisspeptin-54 product of the KISS1 gene, sharing the C-terminal RF-amide motif that all family members require for receptor binding. The peptides were first isolated from human placenta in 2001 and identified as the natural ligands of the orphan G protein-coupled receptor GPR54, now designated KISS1R.
Its position in the reproductive axis is upstream of everything else on this page. Kisspeptin neurons in the hypothalamus signal through KISS1R on GnRH neurons, and that input is what drives pulsatile GnRH release; the pituitary gonadotropins and, downstream of them, gonadal steroids follow from it. Human genetics established the hierarchy directly: loss-of-function variants in GPR54 were found in patients with idiopathic hypogonadotropic hypogonadism, and the receptor was described as a key regulator of the biology of puberty.
Human physiology studies then tested the pathway pharmacologically. Intravenous kisspeptin-54 infusion in male volunteers raised plasma LH, FSH and testosterone against saline control, and later work with kisspeptin-10 reported a rapid, dose-dependent rise in serum LH after bolus administration, with continuous infusion altering LH pulse frequency and pulse size. Compared with a direct gonadotropin such as hCG, kisspeptin acts several steps higher in the axis and depends on the hypothalamic-pituitary machinery below it remaining intact.
Published research
16 peer-reviewed studies on Kisspeptin-10 are summarised in our research library, including 12 published since 2023 — with study designs, reported findings and what the evidence does not establish.
Read the Kisspeptin-10 evidence baseFor research purposes only. Not for human consumption, diagnosis, treatment, or prevention of any condition.
Categorised as Hormones — GH secretagogues, recombinant GH and gonadotropins.
Dosing at a glance
What the literature reports.
For research and laboratory use only. Not for human consumption.
Route
Subcutaneous
Frequency
Single bolus or continuous infusion in study designs
Reported range
100–800 mcg
Protocol duration
Single-session to multi-week protocols
100 mcgper administration800 mcg
Human studies dose kisspeptin-10 on a per-kilogram basis and by the intravenous route: the 2011 work used bolus amounts around 0.3–3 mcg per kg, reporting maximal LH stimulation near 1 mcg per kg, and separately ran continuous infusions expressed in pmol/kg/min. Converted to whole-administration amounts at typical adult bodyweights, those figures span roughly the 100–800 mcg range shown. All figures describe research protocols and the routes used in them.
Ranges reflect protocols reported in the published literature on Kisspeptin-10 — see research citations.
Calculate a dilutionReconstitution & storage
From powder to solution.
- Step 01
Add 2 ml bacteriostatic water
Aim the stream at the vial wall rather than the powder.
- Step 02
Swirl gently — never shake
Rotate the vial until the solution runs clear. Agitation degrades the peptide.
- Step 03
Refrigerate at 2–8 °C
Reconstituted vials belong in the fridge, protected from direct light.
- Step 04
Use within 28 days
Discard any remainder once the stability window closes.
Lyophilised · −20 °CReconstituted · 2–8 °C, 28 days
Reconstituted solution is typically held at 2–8 °C and protected from light; sealed lyophilised vials are stored at -20 °C.
Reconstitution calculator
10 mg vialmg
ml
mcg
250 mcg = 0.25 mg
Draw
5units · U-100 insulin syringe
- Concentration
- 5 mg/ml
- Draws per vial
- 40
- Cost per draw
- €1.25
For research and laboratory use only. Not for human consumption.
Laboratory arithmetic for Kisspeptin-10 — enter the COA-verified vial content for exact figures. Not medical advice.
Effect timeline
Observed across the research window.
Milestones summarise findings reported in the cited studies. Outcomes vary across models and protocols.
Minutes 0–30
Rapid LH response
Bolus administration in men produced a rapid and dose-dependent rise in serum LH, with the reported maximum stimulation occurring near 1 mcg per kg and measured at the 30-minute time point.
Hours 1–2
Full axis response
A 90-minute infusion of kisspeptin-54 in male volunteers raised plasma LH, FSH and testosterone relative to saline control — the observation that established pharmacological activity of the family across the whole hypothalamic-pituitary-gonadal axis.
Continuous infusion
Pulse-pattern changes
Under continuous administration, investigators recorded changes in LH pulse frequency and pulse size alongside a rise in testosterone, indicating action on the pulse generator rather than a simple one-off release.
Reference genetics
Where the pathway sits
Loss-of-function variants in GPR54 identified in patients with idiopathic hypogonadotropic hypogonadism, together with the matching mouse model, placed this receptor upstream of GnRH release and defined it as a regulator of the biology of puberty.
For research and laboratory use only. Not for human consumption.
Scientific research
The published evidence.
The dosing ranges and timeline milestones on this page summarise the peer-reviewed publications below.
References
- 01
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem (2001). PubMed · 11457843
- 02
The GPR54 gene as a regulator of puberty. N Engl J Med (2003). PubMed · 14573733
- 03
Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab (2005). PubMed · 16174713
- 04
Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J Clin Endocrinol Metab (2011). PubMed · 21632807
Laboratory verification
One Certificate, published unaltered.
The Certificate is a test report from a named laboratory outside AKH, ordered by our manufacturer and shown here exactly as the laboratory issued it. A printed copy ships in every parcel.
- Batch
- 26108
- Test date
- 04 Aug 2026
- Task ID
- #1812404
- Purity
- 99.54%
Results
Kisspeptin-10: 10mg | Purity: 99.54%
Verified by Brown Institute of Biomolecular Research. Scan the full report for every measurement.
Product FAQ
Questions researchers ask.
Hormones
